PKR in Fish & Amphibians: Unique Features & Evolution
This research article examines the evolution and function of PKR, a double-stranded RNA-activated protein kinase, in various fish and amphibian species. The authors identify several previously unknown PKR genes, demonstrating the coexistence of PKR and PKZ, another eIF2α kinase with Z-DNA binding domains, in zebrafish. Phylogenetic analyses show that fish PKR genes are more closely related to PKZ genes than to PKR genes of other vertebrates, suggesting an early duplication event in the fish lineage. The paper further investigates the genomic organization of PKR and PKZ genes in different species, revealing tandem gene arrangements and lineage-specific amino acid substitutions. Functional experiments using yeast demonstrate that zebrafish PKR and PKZ can phosphorylate eIF2α, confirming their role as eIF2α kinases. This research provides valuable insights into the evolution of PKR, its role in host defence against viruses, and the potential importance of genetic heterogeneity in the PKR/PKZ system for immune system function. https://researchgate.net/
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https://researchlounge.org/natural-sciences/biology/pkr-in-fish-amphibians-unique-features-evolution/