Repression of telomere associated genes by microglia activation in neuropsychiatric disease
This research paper explores the relationship between microglia activation, telomere biology, and neuropsychiatric disease. The authors investigated the expression of genes involved in telomere maintenance, mitochondrial biogenesis, and cell cycle regulation in microglia under different conditions: LPS- and IL-4-stimulated microglia in vitro, and microglia isolated from mice models of stroke, Alzheimer’s disease, and chronic stress. Notably, they found that classical microglia activation (M1) strongly represses genes associated with the telomere complex, particularly Tert, which encodes the catalytic subunit of telomerase. This suggests a potential link between microglia activation, telomere dysfunction, and neuropsychiatric disease. https://researchgate.net/
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